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The Facilities for Illness Management and Prevention and Nationwide Middle for Immunization and Respiratory Illnesses have offered up to date outcomes of a preliminary evaluation of the H5N1 viruses recognized in two human infections detected in Cambodia in 2023 primarily based on their genetic sequences and provides an replace on the epidemiological investigation.
On February 26, 2023, the Institut Pasteur du Cambodge, in collaboration with the Cambodian Ministry of Well being, shared the total genetic sequence of the H5N1 virus recovered from the affected person who died in that nation on February 22, 2023.
The genetic sequence of the second case was later additionally shared by the Institut Pasteur du Cambodge. CDC has performed a preliminary evaluation of the genetic sequences of those H5N1 chook flu viruses.
They’re H5N1 viruses from clade 2.3.2.1c, that are totally different from the H5N1 viruses now spreading in U.S. wild birds and poultry, that are from clade 2.3.4.4b. These viruses are much like previous 2.3.2.1c viruses detected in that geographic space over latest years.
The genetic sequences counsel that an present clade 2.3.2.1c candidate vaccine virus (CVV), referred to as NIBRG-301 (A/duck/Vietnam/NCVD-1584/2012-like) would supply safety towards the viruses recognized in Cambodia.
Moreover, there have been no genetic adjustments recognized which can be identified to be related to elevated capability to unfold to individuals or cut back susceptibility to influenza antiviral medicine.
CDC had requested virus samples from each circumstances in Cambodia to be able to conduct extra laboratory testing/evaluation to verify these and different traits of the viruses and to offer a extra detailed threat evaluation.
CDC continues to assist the Ministry of Well being, Ministry of Agriculture, Animal, Forestry and Fisheries, and Ministry of Surroundings, in its ongoing One Well being investigation.
Proof up to now continues to assist the conclusion that these two human infections are the results of two cases of bird-to-human unfold. There’s nonetheless no indication of person-to-person unfold related to these two circumstances.
The investigation has revealed that each sufferers grew to become sick at about the identical time and had been possible uncovered to sick or useless poultry previous to turning into unwell, together with being close to sick/useless poultry saved in a coop beneath the home or by butchering, cleansing, and cooking hen that died.
Investigation and containment efforts proceed, together with monitoring and/or testing of contacts of the 2 circumstances for 10 days after their final publicity, together with energetic surveillance for influenza-like-illness within the village. CDC will present extra updates as wanted.
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