Other Drugs, Alcohol, and More

Xyrem (sodium Oxbate) is a prescribed drug that’s used to deal with the signs of narcolepsy. It may well work together with alcohol in addition to different medicines that trigger drowsiness. For example, Xyrem can work together with zolpidem (Ambien).

Xyrem can be utilized to deal with these illnesses in kids and adults with narcolepsy:

Xyrem is a liquid answer you swallow. It’s a supply of lively ingredient sodium oxybate. (An lively ingredient is what makes a drug carry out.)

An interplay might be attributable to a substance that causes one other substance to provide an reverse impact than was anticipated. Interactions may also happen once you endure from sure well being circumstances.

Learn on to study extra in regards to the potential interactions Xyrem may have. For extra particulars about Xyrem, together with details about its purposes, take a look at this text.

Earlier than you start taking Xyrem for the primary time, inform your pharmacist and physician relating to any prescriptions, over-the counter or different medicines you take. Informing them about this data may help to keep away from interactions. (To seek out out if Xyrem interacts with herbs, dietary supplements and nutritional vitamins, discuss with the “Are there different interactions with Xyrem?” part under.)

If in case you have any considerations relating to drug interactions that might have an effect on you, converse to your doctor or pharmacist.

The next desk lists a wide range of medicine that may work together with Xyrem. Remember that this desk doesn’t embody all medicine that may have interactions with Xyrem. For extra particulars on sure interactions, take a look at the “Drug interactions defined” part under.

* Sedatives are often known as sedative hypnotics or prescribed sleep aids. To seek out out extra about Xyrem’s interactions these medicines, learn the “When ought to I keep away from Xyrem?” part under.

Sure medical circumstances or different elements could enhance your threat of hurt if take Xyrem. In these instances your physician won’t suggest Xyrem to you. These are known as contraindications. The next checklist consists of the Xyrem contraindications.

If in case you have succinic semialdehyde dehydrogenase deficiency. Should you endure from an unusual genetic (inherited) situation referred to as succinic semialdehyde hydroxygenase deficiency taking Xyrem may enhance the possibility of experiencing opposed unfavorable results from the drug. It’s because this situation can result in Xyrem to construct inside your physique. As an alternative of prescribing Xyrem your physician could counsel various remedies which might be extra secure for you.

In case you are taking the sedatives or drink alcohol. Xyrem is a central nervous system (CNS) depressant. This implies it may gradual the mind’s alerts that management important bodily features. This might result in respiratory despair (slowed respiratory). CNS depressants might also trigger sleepiness (extreme sleepiness).

It isn’t beneficial to take Xyrem together with different CNS depressants, like alcohol or sedatives. (These are substances that induce drowsiness and likewise embody sleep aids such because the zolpidem.) Combining these substances or medicine with Xyrem may lead to extreme sedation or a dangerously gradual respiratory. Should you use sedatives, or drink alcohol or devour alcohol, your physician is not going to suggest Xyrem for you. They might counsel various remedy choices that might be extra applicable for you.

Earlier than you start taking Xyrem seek the advice of your physician to find out if any of the problems which might be listed above pertain to you. Your physician will decide whether it is secure to take.

* Xyrem comes with an enclosed warning about the potential for CNS despair. Essentially the most extreme warning comes within the type of a boxed warning issued by the Meals and Drug Administration (FDA). For extra data, go to “Boxed warnings” initially of this text.

It isn’t beneficial to drink alcohol throughout Xyrem remedy.

Xyrem in addition to alcohol are each central nervous methods (CNS) depressants. Which means that they each inhibit the mind’s alerts to are used to handle important bodily features. Which means that the drug could trigger respiratory despair (slowed respiratory). As well as, each Xyrem and alcohol could trigger the situation of sedation (extreme Drowsiness). Combining alcohol and Xyrem may enhance the possibility of extreme sedation respiratory despair, or each.

In case you are involved about ingesting alcohol while you’re taking Xyrem remedy, seek the advice of your pharmacist or physician. They could suggest a unique remedy for you.

* Xyrem comes with an enclosed warning about the potential for CNS despair. Boxed warnings are a very powerful warning issued by the Meals and Drug Administration (FDA). For extra data, discuss with “Boxed warnings” initially of this text.

Discover out extra about particular interactions between medicine that may be attributable to Xyrem.

Interactions with benzodiazepines

Xyrem could work together with benzodiazepines, which might be used to deal with nervousness that’s short-term in addition to different indicators of psychological well being points. In some situations, a benzodiazepine might be prescribed to individuals loosen up and put together previous to present process an operation that’s medically essential.

Examples of benzodiazepines are:

What’s the potential for what may happen?

Xyrem and benzodiazepines could trigger sleepiness. Subsequently, taking these two medicine collectively may enhance your threat of getting this aspect impact. It may additionally make this opposed response extra severe.

What you are able to do

In case you are taking Xyrem and it’s essential take an benzodiazepine for a short length the physician could suggest that you simply take a break from Xyrem. Nevertheless, if you’re taking a benzodiazepine remedy repeatedly your physician may prescribe an Xyrem dose that’s decrease for you. It isn’t beneficial to take any increased dose of any remedy than what the physician recommends.

Should you’re taking Xyrem and a benzodiazepine together and you’re experiencing an issue, inform your physician instantly if you happen to expertise an excessive drowsiness, which isn’t the conventional drowsiness that you simply expertise once you endure out of your situation.

If in case you have any questions relating to the usage of Xyrem with benzodiazepines speak along with your doctor or pharmacist.

Interplay with opioids

Xyrem could also be a drug that interacts with opioids. It is a class of medication that features prescription painkillers in addition to unlawful substances like heroin.

Examples of opioids prescribed to deal with excessive ache are:

What’s the potential for what may happen?

Xyrem is a central nervous system (CNS) depressant. This implies it could scale back sure mind alerts which might be used to handle important physique features. Which means that the drug can set off respiratory despair (slowed respiratory). CNS depressants may also set off sleepiness (extreme Drowsiness).

Opioids additionally perform as CNS depressants. Combining these two medicine may lead to extreme sedation or a dangerously gradual respiratory. These results are comparable as those who happen in an overdose of opioids that might be life-threatening.

* Xyrem comes with an unboxed warning relating to the potential for CNS despair. Boxed warnings are a very powerful warning issued by the Meals and Drug Administration (FDA). For extra data, go to “Boxed warnings” initially of this text.

What you are able to do

In case you are taking Xyrem and require an opioid-based painkiller for a short length the physician could suggest that you simply discontinue taking Xyrem. Nevertheless, if you’re taking an opioid remedy continuously, your physician may suggest a decrease dose of Xyrem for you. You shouldn’t take any increased dose of any remedy than your physician recommends.

In case you are taking Xyrem and an opioid together Your physician could suggest retaining the naloxone (Narcan, RiVive, others) nasal (nostril) spray in your bag to guard your self. The drug is utilized in a scenario of emergency to counter the impact of opioids in addition to to revive common respiratory. Naloxone could be prescribed by your physician or you possibly can ask for it out of your pharmacy for gratis with out prescription. For extra data on Naloxone, converse to your doctor or pharmacist.

If in case you have extra questions relating to the usage of Xyrem together with opioids, converse along with your doctor or pharmacist.

Interactions with divalproex (Depakote, Depakote ER)

Xyrem could intrude with divalproex (Depakote, Depakote ER). This drug is used for treating epilepsy in addition to sure psychological well being points, resembling bipolar dysfunction.

What can occur?

The usage of Xyrem with divalproex may enhance the quantity of Xyrem in your physique, which may enhance the chance of opposed results.

Xyrem is a central nervous system (CNS) depressant. These medicines can gradual or have an effect on the mind’s features, resembling these associated to reminiscence and pondering. Combining divalproex with Xyrem may enhance the chance of opposed unwanted side effects or trigger them to grow to be extra extreme. In analysis, taking each divalproex and Xyrem prompted it to be more durable for individuals to focus and recall issues.

What you are able to do

In case you are taking Xyrem and Depakote your physician could prescribe a dosage of Xyrem that’s decrease than the standard. You shouldn’t take an elevated dose of both of the medicines than your physician recommends.

In case you are taking Xyrem along with Depakote collectively, inform your physician instantly once you expertise any new or extra extreme opposed reactions to Xyrem.

If in case you have any questions regarding the usage of Xyrem with Depakote seek the advice of your pharmacist or physician.

Xyrem may additionally trigger different reactions. They’ll happen once you take dietary supplements, meals gadgets in addition to vaccines or laboratory exams. Take a look at the next for extra data. Please word that the data offered under doesn’t cowl another interactions that might happen with Xyrem.

Do Xyrem intrude with different dietary supplements?

Earlier than you start taking Xyrem for the primary time, converse to your pharmacist and physician about any natural dietary supplements, dietary supplements and nutritional vitamins you take. Informing them of this data may help you keep away from any attainable interactions.

If in case you have any questions relating to interactions that might have an effect on you talk about it along with your pharmacist or physician.

Interactions between herbs and Xyrem

Xyrem may intrude with an herb referred to as St. John’ wort which is used to alleviate signs of despair and different problems. The mix of Xyrem along with St. John’s wort could trigger extreme sedation or worsened results of Xyrem.

Moreover, Xyrem and a few herbs may set off sure opposed results, together with sleepiness. For example, some individuals use chamomile or valerian dietary supplements to assist in sleeping. In case you are taking these herbs throughout your Xyrem remedy you possibly can have the next likelihood of really feel drowsy. This aspect impact could also be extra extreme than once you take Xyrem by itself.

This is the reason it’s vital to seek the advice of your doctor or pharmacist previous to taking any of those medicines that comprise Xyrem.

Xyrem and nutritional vitamins

There aren’t any reviews but of Xyrem interfering with nutritional vitamins. Nevertheless, this doesn’t imply vitamin interactions is not going to be noticed within the close to future.

This is the reason it’s important to speak along with your physician or pharmacist previous to utilizing any of those medicine when you find yourself taking Xyrem.

Do Xyrem intrude with meals?

There’s been no reported situations of Xyrem interplay with particular meals gadgets. Nevertheless, it is very important wait a minimum of two hours after having eaten earlier than taking your first dose of Xyrem. Should you take Xyrem earlier than consuming (or too shortly after consuming) can decrease the degrees of the drug inside your physique. This might trigger Xyrem much less environment friendly.

Is Xyrem interfer with vaccines?

There aren’t any reported instances of Xyrem interplay with vaccines. If in case you have any questions relating to the vaccinations you’ll obtain throughout your Xyrem remedy seek the advice of your physician.

Does Xyrem intrude with laboratory exams?

Tright here aren’t any reviews of Xyrem interplay with laboratory exams. If in case you have considerations in regards to the want for sure lab exams performed in the course of the remedy course of with Xyrem talk about it with the healthcare skilled who ordered the check.

Does Xyrem have an interplay CBD or hashish?

Hashish (generally referred to as marijuana) and cannabis-related merchandise resembling cannabidiol (CBD) have been particularly linked to Xyrem.

Xyrem and hashish are each central nervous system (CNS) depressants. Which means that they each scale back sure brain-related alerts which might be used to handle vital bodily features, like respiratory and pondering. Which means that each can set off respiratory despair (slowed respiratory) and sleepiness (extreme tiredness). Combining hashish and Xyrem can enhance the chance of those issues.

Xyrem comes with a boxed warning about the potential for CNS despair. That is probably the most extreme warning issued by the FDA. For extra data, discuss with “Boxed warnings” on the prime of this text.

Word: Hashish is unlawful on the federal degree nonetheless it’s authorized in a number of states to totally different ranges.

Some medical circumstances and different elements can enhance the chance of interplay with Xyrem. Earlier than you’re taking Xyrem talk about along with your physician relating to your medical background. They’ll resolve if Xyrem is the correct selection for you.

Different circumstances, well being points or different features that might have an effect on Xyrem embody:

Respiratory points. Xyrem could trigger respiratory despair (slowed respiratory) or problem respiratory. If in case you have respiratory issues, like sleep apnea, then taking Xyrem may make your situation worse.

Succinic semialdehyde dehydrogenase insufficiency. Taking Xyrem will not be beneficial for these with this situation. For extra data, discuss with the “When ought to I keep away from Xyrem?” part above.

Liver points. Should you endure from a liver difficulty like liver failure or liver failure, the Xyrem degree may enhance inside your physique. This might enhance your likelihood of experiencing opposed results of the remedy. Due to the chance of this, docs sometimes counsel a lesser dose of Xyrem to these affected by liver points. To seek out out extra, seek the advice of along with your doctor.

A low-salt food regimen. Earlier than beginning Xyrem remedy, inform your physician if you’re on an consuming plan that’s low in salt. This might imply the usage of a low salt food regimen to deal with coronary heart failure or hypertension or kidney points.

Xyrem incorporates a big amount of salt. You may wish to take into consideration the quantity of salt you devour to trace your each day consumption of salt. To seek out out the amount of salt contained in every dose of Xyrem take a look at the prescribing data for the drug.

Being pregnant. It’s not identified whether or not Xyrem is secure to make use of throughout being pregnant. Should you’re planning or pregnant to grow to be pregnant, seek the advice of your physician previous to taking Xyrem.

breastfeeding. It’s not identified whether or not it’s secure to make use of Xyrem throughout breastfeeding. The drug could be present in breast milk, however it’s not sure if it is going to trigger opposed results in a baby that’s breastfeeding. Should you’re breastfeeding or plan to breastfeed, converse along with your physician about choices.

Allergy response. Should you’ve had an allergic response to Xyrem or any of its components your physician will in all probability not suggest Xyrem. It’s because taking the drug could trigger a second allergic response. Ask your doctor about various remedies that is likely to be a more sensible choice for you.

Following just a few steps can help you in avoiding interactions with Xyrem. Earlier than starting remedy, converse along with your pharmacist and physician. The matters to speak about with them are:

• Regardless of if you happen to devour alcohol or use hashish.
• Different medicines you take together with any dietary supplements, nutritional vitamins, and natural dietary supplements. Your pharmacist or physician could help you in filling out the remedy checklist.
• What must you do if start taking a brand new remedy while you’re present process Xyrem remedy.

It’s additionally vital to know the label for Xyrem in addition to different documentation that might be included together with the remedy. The coloured stickers that specify interactions might be discovered included on the label. Additionally, the documentation (generally referred to as the insert for the affected person’s bundle or the remedy information) may comprise extra data relating to interactions. (Should you didn’t obtain the paperwork for Xyrem, request your pharmacist to print one for you.)

In case you are having bother comprehending or studying the data offered, your doctor or pharmacist can help you.

The precise dosage of Xyrem may also assist keep away from interactions.

Should you’re nonetheless uncertain about Xyrem and the attainable interactions, converse to your physician.

Questions you may be capable to ask your physician are:

• What’s the greatest schedule for me to take Xyrem together with my different medicines to forestall interactions?
• Do increased doses of Xyrem enhance my likelihood of interplay with different medicines?
• Are various choices to Xyrem that received’t intrude with alcohol?

To seek out out extra about Xyrem’s capabilities, learn these articles:

To study extra about totally different well being circumstances and suggestions for bettering your well being, join one of many Healthline newsletters. You may also wish to discover the communities on the web at Bezzy. It’s a group the place individuals with particular circumstances can get assist and join with different individuals.

Disclaimer: This data will not be meant to be substitute for the expertise and experience of licensed healthcare professionals. At all times seek the advice of along with your doctor or different healthcare skilled previous to utilizing any medication. The details about medicine on this article is topic to modifications and isn’t meant to offer all attainable instructions, makes use of or precautions, warnings or reactions to medicine or allergic reactions. opposed reactions. Within the absence of any warnings or different particulars relating to the drug in query doesn’t imply that the remedy or mixture is secure or efficient for all sufferers or particular purposes.

Article supply and credit to https://www.healthline.com/well being/medicine/xyrem-interactions